P. Uncovering one of humankind's most ancient Khoisan lineages

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December 4, 2014 SCIENCE DAILY

Nanyang Technological University

Scientist at Nanyang Technological University (NTU Singapore) and Penn State University in the United States have successfully discovered one of modern humans' ancient lineages through the sequencing of genes.

A geneticist from NTU, Professor Stephan Christoph Schuster, who led and international research team from Singapore, United States and Brazil, said this is the first time that the history of humankind populations has been analysed and matched to Earth's climatic conditions over the last 200'000 years.

Their breakthrough findings are published today (4 Dec 2014) in Nature Communications.

The team has sequenced the genome of five living individuals from a hunter/gatherer tribe in Southern Africa, and compared them with 420'000 genetic variants across 1,462 genomes from 48 ethnic groups of the global populations.

Through advanced computation analasys, the team found that these Southern African Khoisan tribespeople are genetically distinct not ony from Europeans and Asians, but also from all other Africans.

The team also found that there are individuals of the Khoisan population whose ancestors did not interbreed with any of the other ethnic groups of humans for most of that time until about 20'000 years ago.

Their findings mean it is now possible to use genetic sequencing to reveal the ancestral lineage of any ethnic group even to 200'000 years ago, if non-admixed individuals are found, like in the case of the Khoisan. This will show when in history there have been important genetic changes to an ancestral lineage due to intermarriages or geographical migrations that may have occured over the centuries.

"Khoisan hunter / gatherers in Southern Africa have always perceived themselves as the oldest people", said Prof. Schuster, an NTU scientist at the Singapore Centre on Environmental Life Sciences Engineering (SCELSE) and a former Penn State university professor.

"Our study prove that they truly belong to one of mankind's most ancient lineages, and these high quality genome sequences obtained from the tribesmen will help us better understand human population history, especially the understudied branch of mankind such as the Khoisan."

"The new data gathered will also enable scientists to better understand how the human genome has envolved and hopefully lead to more effective treatment options for certain genetic diseases and illnesses".

Of the five tribesmen who were the oldest members of the Ju/'hoansi tribe and other tribes living in protected areas of northwest Namibia, two individuals were found to have a genome which had not admixed with other ethnic groups.

The Ju/'hoansi tribe was made famous in the 80s and 90s by the box-office hit movie series "The Gods Must Be Crazy." The main character of the series was a hunter/gatherer tribesman, played by N!xau, a bushman.

The research paper's first author, Dr Hie Lim Kim, a SCELSE senior research fellow, said "it was very surprising that this group apparently did not intermarry with non-Khoisan neighbours for thousands of years." This is because the Khoisan peoples and the rest of modern humanity shared their most recent common ancestor around 150,000 years ago.

The current Khoisan culture and tradition, where marriage occurs either among Khoisan groups or results in female members leaving their tribes after marrying non-Khoisan culture and tradition,appears to be long-standing.

"A key finding from this study is that even today after 150,000 years, single non-admixed individuals or descendants of those who did not interbreed with separate populations can be identified within the Ju/'hoansi population, which means there might be more of such unique individuals in other parts of the world," added Dr Kim.

The Khoisan tribespeople participating in this study had parts of their genomes sequenced in an earlier study by the same team in 2010. The new study generated complete genome sequences at high quality, which enabled the analysis of admixture and population history. The availability of such high quality Southern African genomes will allow further investigation of the population history of this largely understudied branch of humankind at high resolution.

This research project involving six investigators was led by NTU and Penn State University and Sao Paulo State University, Brazil.



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